More than twice as many Labs were registered last year than any other breed, the club said in a statement.
The Yorkshire Terrier came in second place, followed by the German shepherd, the golden retriever, the beagle, the boxer and the dachshund.
The bulldog is moving up the list with a 69 per cent increase in the past decade, jumping two spots this year to No. 8. Last year, it made the top 10 for the first time in 70 years.
"The playful Lab may still reign supreme, but the docile and adaptive nature of the bulldog is gaining ground as a family favourite," said American Kennel Club spokesperson Lisa Peterson.
The poodle and the shih tzu completed the top 10.
Other breeds on the rise over the past decade are the miniature bull terrier, up 109 per cent, the bull terrier (102 per cent), Staffordshire bull terrier (69 per cent) and the bullmastiff (22 per cent).
Among the breeds on the decline are the lhasa apso, which is down 80 per cent, Rottweiler (down 76 per cent), schipperke (75 per cent), the basset hound (66 per cent) and the miniature pinscher (75 per cent).
The Labrador retriever is the most popular pure-bred dog in the United States for the 18th consecutive year, according to the American Kennel Club.